Silencing efficacy prediction: a retrospective study on target mRNA features
نویسندگان
چکیده
منابع مشابه
Silencing efficacy prediction: a retrospective study on target mRNA features
Post-transcriptional gene silencing is a widely used method to suppress gene expression. Unfortunately only a portion of siRNAs do successfully reduce gene expression. Target mRNA secondary structures and siRNA-mRNA thermodynamic features are believed to contribute to the silencing activity. However, there is still an open discussion as to what determines siRNA efficacy. In this retrospective s...
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ژورنال
عنوان ژورنال: Bioscience Reports
سال: 2015
ISSN: 0144-8463,1573-4935
DOI: 10.1042/bsr20140147